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Researchers / Funded Pilot Projects
Funded Pilot Projects
As one of its research missions, the Alzheimer Disease Research Center (ADRC) at the University of Pittsburgh funds one year pilot projects to stimulate new and innovative research relevant to Alzheimer's disease. Types of research can range from basic science to psychosocial in methodology, with particular attention given to novel approaches. Proposed research may involve humans, other animals or in vitro studies. Particular attention is paid to the likelihood that subsequent extramural peer reviewed funding would ensue, since that is the NIA's purpose in providing these funds.
- 2007-2008
- Potential role for neuronal mitochondrial dynamics in Alzheimer’s disease: Response to APP and APpsw expression
- Sarah Berman, M.D., Ph.D.
- 2006-2007
- Antiapoptotic Binding of Cytochrome C and Peroxidative Aggregation of alpha Synuclein
- Hulya Bayir, M.D.
- Familiarity Impairment in Amnestic Mild Cognitive Impairment: Behavioral and Structural MRI Correlates
- David A. Wolk, MD, Assistant Professor of Neurology, University of Pittsburgh
- 2005-2006
- Molecular understanding of Aß peptide interactions with extracellular Alpha-synuclein
- Pravat K. Mandal, Ph.D., Assistant Professor of Psychiatry, University of Pittsburgh
- Alpha-Synuclein: Potential Effect on Tau and Lewy Body Dementia
- Ruth G. Perez, Ph.D., Assistant Professor of Neurology, University of Pittsburgh
- 2004-2005
- The Role of Presenilin Complex Assembly and Trafficking in Alzheimer's Disease
- Meir Aridor, PhD, Assistant Professor of Cell Biology and Physiology University of Pittsburgh
- PET Detection of Macrophages in AD
- Clayton A. Wiley, MD, PhD, Professor of Pathology, University of Pittsburgh
- 2003-2004
- LXR Ligands, Cholesterol Efflux and Abeta Generation
- Iliya Lefterov, MD, PhD, Research Assistant Professor of Pharmacology, University of Pittsburgh | Radosveta P. Koldamova, MD, PhD, Instructor of Pharmacology, University of Pittsburgh
- Exploration of the Validity of "Pain" Behaviors in Alzheimer's Disease
- Debra K. Weiner, MD, Associate Professor of Medicine, Psychiatry, & Anesthesiology, University of Pittsburgh
- 2002-2003
- Optimization of Cerebral Perfusion Imaging for Dementia
- H. Michael Gach, Ph.D., Assistant Professor, University of Pittsburgh Department of Radiology, Primary Investigator | Tao Li, Ph.D., M.D., University of Pittsburgh Department of Radiology, Co-Investigator | Carolyn C. Meltzer, M.D., University of Pittsburgh Department of Radiology, Co-Investigator | Oscar L. Lopez, M.D., University of Pittsburgh Department of Neurology, Co-Investigator
- Associations for Alzheimer's Disease with Psychosis Using Positional Candidate Genes
- Vishwajit L. Nimgaonkar, M.D., Ph.D., University of Pittsburgh, Principal Investigator | Robert A. Sweet, M.D., University of Pittsburgh, Co-Investigator | Silviu-Alin Bacanu, Ph.D., University of Pittsburgh, Co-Investigator
- 2001-2002
- Role of Estrogen in Metallothionein Expression and the Function of Basal Forebrain and Hippocampal Neurons
- Donald DeFranco, PhD, Professor of Pharmacology, University of Pittsburgh
- Mechanism of Apolipoprotein A-1 Protection Against Ab Neurotoxicity
- Radosveta Koldamova, MD, PhD, Instructor of Pharmacology, University of Pittsburgh
- 2000-2001
- In Vivo Imaging of Beta-Amyloid in Alzheimer's Disease
- Yanming Wang, PhD, Assistant Professor of Radiology, University of Pittsburgh
- Reducing Stress and Sleep Disturbances in Caregivers of Alzheimer's Patients
- Martica Hall, PhD, Assistant Professor of Psychiatry | Lynn Martire, PhD, Assistant Professor of Psychiatry, University of Pittsburgh
- 1999-2000
- Implicit Learning in Alzheimer's Disease
- Cameron S. Carter, MD | Howard J. Aizenstein MD, PhD | Robert D. Nebes, PhD
- Presenilin's Role in Differentiation and Apoptosis
- Seth Corey, MD | Sergey Keryanov, PhD
- Functional Studies of an Alpha-2-Macroglobulin Mutant Linked to Alzheimer's Disease
- Charleen T. Chu, MD, PhD
- Role of Physiological Zinc Release and Heat Shock Protein Induction in Beta Amyloid Protein Aggregation
- BethAnn McLaughlin, PhD | Elias Aizenman, PhD
- 1998-1999
- Endothelial Dysfunction in Response to APP695 Expression
- Nadia Jahroudi, PhD
- Development of Gene Therapy for Alzheimer's Disease
- Darren P. Wolfe, PhD | Joseph C. Glorioso, PhD
- 1997-1998
- DNA Binding and Transcriptional Regulation by the FAC1 Protein, a Protein Re-expressed in Alzheimer's Disease
- Kelly Jordan, PhD | Robert Bowser, PhD
- Dopamine Receptor Binding, Psychosis, and Agitation in Alzheimer's Disease
- Robert A. Sweet, MD - The Cellular Source of Neurotrophic Response in Alzheimer's Disease
- Lanling Zou, MD, PhD
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